4-甲基-7H-吡咯并[2,3-d]嘧啶合成路线 （共 3 条）
反应条件
magnesium chloride in tetrahydrofuran
T=20°C; 8 h;
参考文献
Millennium Pharmaceuticals, Inc.
Patent: US2007/191293 A1, 2007 ;
Location in patent: Page/Page column 62 ;
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in diethyl ether; toluene
T=20 - 60°C; Inert atmosphere;
参考文献
Plexxikon, Inc.
Patent: US2009/286783 A1, 2009 ;
Location in patent: Page/Page column 64 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=75°C; 8 h; Inert atmosphere;
参考文献
Thiyagarajan, Anandarajan; Salim, Mohammed T.A.; Balaraju, Tuniki; Bal, Chandralata; Baba, Masanori; Sharon, Ashoke
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 24 p. 7742 - 7747
