6,7-二氢-2-戊基-苯并[b]噻吩-4(5h)-酮合成路线 （共 3 条）
反应条件
trifluoroacetic acid; trifluoroacetic anhydride
T=20°C; 12 h;
参考文献
Dezi, Cristina; Brea, Jose; Alvarado, Mario; Ravina, Enrique; Masaguer, Christian F.; Loza, Maria Isabel; Sanz, Ferran; Pastor, Manuel
Journal of Medicinal Chemistry, 2007 , vol. 50, # 14 p. 3242 - 3255
反应条件
1.1: AlCl3 / CH2Cl2 / 0.5 h / 0 °C
1.2: 76 percent / CH2Cl2 / 0 - 20 °C
2.1: 70 percent / Zn/Hg; acetic acid; aq. HCl / toluene / 72 h / Heating
3.1: 75 percent / trifluoroacetic acid; trifluoroacetic acid anhydride / 12 h / 20 °C
View Scheme
参考文献
Dezi, Cristina; Brea, Jose; Alvarado, Mario; Ravina, Enrique; Masaguer, Christian F.; Loza, Maria Isabel; Sanz, Ferran; Pastor, Manuel
Journal of Medicinal Chemistry, 2007 , vol. 50, # 14 p. 3242 - 3255
反应条件
1: 70 percent / Zn/Hg; acetic acid; aq. HCl / toluene / 72 h / Heating
2: 75 percent / trifluoroacetic acid; trifluoroacetic acid anhydride / 12 h / 20 °C
View Scheme
参考文献
Dezi, Cristina; Brea, Jose; Alvarado, Mario; Ravina, Enrique; Masaguer, Christian F.; Loza, Maria Isabel; Sanz, Ferran; Pastor, Manuel
Journal of Medicinal Chemistry, 2007 , vol. 50, # 14 p. 3242 - 3255
