6-溴-3-甲氧基吡啶甲酸甲酯合成路线 （共 4 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 4 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2007/89031 A1, 2007 ;
Location in patent: Page/Page column 84-85 ;
WO 2007/089031 A1
反应条件
in methanol; diethyl ether
T=0°C; 2 h;
参考文献
SPEEDEL EXPERIMENTA AG
Patent: WO2007/31558 A1, 2007 ;
Location in patent: Page/Page column 33 ;
WO 2007/031558 A1
参考文献
Zartman, C. Blair; Bell, Ian M.; Gallicchio, Steven N.; Graham, Samuel L.; Kane, Stefanie A.; Mallee, John J.; Rutledge, Ruth Z.; Salvatore, Christopher A.; Vacca, Joseph P.; Williams, Theresa M.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 22 p. 6705 - 6708
反应条件
1: sulfuric acid
2: bromine / water
View Scheme
参考文献
Zartman, C. Blair; Bell, Ian M.; Gallicchio, Steven N.; Graham, Samuel L.; Kane, Stefanie A.; Mallee, John J.; Rutledge, Ruth Z.; Salvatore, Christopher A.; Vacca, Joseph P.; Williams, Theresa M.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 22 p. 6705 - 6708
