5-(4-甲氧基苯基)-1-甲基吡啶-2(1h)-酮合成路线 （共 6 条）
反应条件
1: 5-(4-methoxyphenyl)pyridin-2(1H)-one With lithium hydride in N,N-dimethyl-formamide
T=50°C; 1.5 h;
2: methyl iodide in N,N-dimethyl-formamide
16 h; Further stages.;
参考文献
McCarthy, Anna R.; Hartmann, Rolf W.; Abell, Andrew D.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3603 - 3607
反应条件
1.1: 82 percent / KOH; n-Bu4NBr / Pd(PPh3)4 / tetrahydrofuran / 19 h / Heating
2.1: 100 percent / aq. HCl / dioxane / 24 h / Heating
3.1: LiH / dimethylformamide / 1.5 h / 50 °C
3.2: 68 percent / dimethylformamide / 16 h
View Scheme
参考文献
McCarthy, Anna R.; Hartmann, Rolf W.; Abell, Andrew D.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3603 - 3607
反应条件
1.1: 82 percent / KOH; n-Bu4NBr / Pd(PPh3)4 / tetrahydrofuran / 19 h / Heating
2.1: 100 percent / aq. HCl / dioxane / 24 h / Heating
3.1: LiH / dimethylformamide / 1.5 h / 50 °C
3.2: 68 percent / dimethylformamide / 16 h
View Scheme
参考文献
McCarthy, Anna R.; Hartmann, Rolf W.; Abell, Andrew D.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3603 - 3607
反应条件
potassium carbonate in ethanol; water
T=90°C; Suzuki Coupling; 1 h; Microwave irradiation;
参考文献
Bratt, Emma; Verho, Oscar; Johansson, Magnus J; Baeckvall, Jan-Erling
Journal of Organic Chemistry, 2014 , vol. 79, # 9 p. 3946 - 3954
反应条件
1.1: 100 percent / aq. HCl / dioxane / 24 h / Heating
2.1: LiH / dimethylformamide / 1.5 h / 50 °C
2.2: 68 percent / dimethylformamide / 16 h
View Scheme
参考文献
McCarthy, Anna R.; Hartmann, Rolf W.; Abell, Andrew D.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3603 - 3607
反应条件
hydrogen bromide; acetic acid
16 h; Heating;
参考文献
McCarthy, Anna R.; Hartmann, Rolf W.; Abell, Andrew D.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3603 - 3607
