5-(4-羟基苯基)-1-甲基吡啶-2(1H)-酮合成路线 （共 5 条）
反应条件
1.1: 82 percent / KOH; n-Bu4NBr / Pd(PPh3)4 / tetrahydrofuran / 19 h / Heating
2.1: 100 percent / aq. HCl / dioxane / 24 h / Heating
3.1: LiH / dimethylformamide / 1.5 h / 50 °C
3.2: 68 percent / dimethylformamide / 16 h
4.1: 83 percent / HBr; AcOH / 16 h / Heating
View Scheme
参考文献
McCarthy, Anna R.; Hartmann, Rolf W.; Abell, Andrew D.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3603 - 3607
反应条件
1.1: 82 percent / KOH; n-Bu4NBr / Pd(PPh3)4 / tetrahydrofuran / 19 h / Heating
2.1: 100 percent / aq. HCl / dioxane / 24 h / Heating
3.1: LiH / dimethylformamide / 1.5 h / 50 °C
3.2: 68 percent / dimethylformamide / 16 h
4.1: 83 percent / HBr; AcOH / 16 h / Heating
View Scheme
参考文献
McCarthy, Anna R.; Hartmann, Rolf W.; Abell, Andrew D.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3603 - 3607
反应条件
hydrogen bromide; acetic acid
16 h; Heating;
参考文献
McCarthy, Anna R.; Hartmann, Rolf W.; Abell, Andrew D.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3603 - 3607
反应条件
1.1: LiH / dimethylformamide / 1.5 h / 50 °C
1.2: 68 percent / dimethylformamide / 16 h
2.1: 83 percent / HBr; AcOH / 16 h / Heating
View Scheme
参考文献
McCarthy, Anna R.; Hartmann, Rolf W.; Abell, Andrew D.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3603 - 3607
反应条件
1.1: 100 percent / aq. HCl / dioxane / 24 h / Heating
2.1: LiH / dimethylformamide / 1.5 h / 50 °C
2.2: 68 percent / dimethylformamide / 16 h
3.1: 83 percent / HBr; AcOH / 16 h / Heating
View Scheme
参考文献
McCarthy, Anna R.; Hartmann, Rolf W.; Abell, Andrew D.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3603 - 3607
