2-氯-5-硝基苯磺酸钠合成路线 （共 10 条）
反应条件
sodium hydroxide; sulfuric acid T=110 - 115°C; 16 h;
参考文献
Suzuki, Hiroshi; Yazawa, Naoto; Yoshida, Yasuo; Furusawa, Osamu; Kimura, Yoshikazu
Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 7 p. 2010 - 2017
反应条件
sodium hydroxide in water T=20°C; 1 h;
参考文献
Pan, Li; Jiang, Ying; Liu, Zhen; Liu, Xing-Hai; Liu, Zhuo; Wang, Gang; Li, Zheng-Ming; Wang, Di
European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 18 - 26
反应条件
1: 80 percent / phosphoryl chloride / acetonitrile; tetrahydrothiophene 1,1-dioxide; N,N-dimethyl-acetamide / 1 h / 70 °C 2: 90 percent / Ph4PBr, KF / tetrahydrothiophene 1,1-dioxide / 16 h / 130 - 140 °C 3: KF, PPh4Br / tetrahydrothiophene 1,1-dioxide; toluene / 210 °C / 300 Torr View Scheme
参考文献
Suzuki, Hiroshi; Yazawa, Naoto; Yoshida, Yasuo; Furusawa, Osamu; Kimura, Yoshikazu
Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 7 p. 2010 - 2017
参考文献
Fuji Photo Film Co., Ltd.
Patent: US4310693 A1, 1982 ;
反应条件
trichlorophosphate in sulfolane; acetonitrile T=68 - 72°C; 0.666667 h;
参考文献
Fujita, Shinsaku
Synthesis, 1982 , # 5 p. 423 - 424
反应条件
1: trichlorophosphate / acetonitrile; isobutyramide / 3 h / Reflux 2: ammonia / water / 1 h / 20 °C View Scheme
参考文献
Pan, Li; Jiang, Ying; Liu, Zhen; Liu, Xing-Hai; Liu, Zhuo; Wang, Gang; Li, Zheng-Ming; Wang, Di
European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 18 - 26
反应条件
1: chlorosulfonic acid / 4 h / 5 - 130 °C 2: ammonia / water / 10 - 20 °C 3: palladium 10 on activated carbon; hydrogen / methanol / 4 h / 50 °C View Scheme
参考文献
Pan, Li; Jiang, Ying; Liu, Zhen; Liu, Xing-Hai; Liu, Zhuo; Wang, Gang; Li, Zheng-Ming; Wang, Di
European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 18 - 26
反应条件
sulfuric acid; nitric acid
参考文献
Pollitt,R.J.
Journal of the Chemical Society, 1965 , p. 6198 - 6201
反应条件
1: trichlorophosphate / acetonitrile; isobutyramide / 3 h / Reflux
2: ammonia / water / 1 h / 20 °C
3: ammonia; (NH4)2CO3; copper(II) sulfate / water / Reflux
View Scheme
参考文献
InterMune, Inc.
Patent: US2011/152246 A1, 2011 ;
反应条件
1: 80 percent / phosphoryl chloride / acetonitrile; tetrahydrothiophene 1,1-dioxide; N,N-dimethyl-acetamide / 1 h / 70 °C
2: 90 percent / Ph4PBr, KF / tetrahydrothiophene 1,1-dioxide / 16 h / 130 - 140 °C
3: KF, PPh4Br / tetrahydrothiophene 1,1-dioxide; toluene / 210 °C / 300 Torr
View Scheme
参考文献
Suzuki, Hiroshi; Yazawa, Naoto; Yoshida, Yasuo; Furusawa, Osamu; Kimura, Yoshikazu
Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 7 p. 2010 - 2017
