2-氟-3-硝基苯甲酸甲酯合成路线 （共 7 条）
反应条件
sulfuric acid T=70°C;
参考文献
GLAXOSMITHKLINE LLC; ADAMS, Jerry, Leroy; FAITG, Thomas; KASPAREC, Jiri; PENG, Xin; RALPH, Jeffrey; RHEAULT, Tara Renae; WATERSON, Alex Gregory
Patent: WO2011/59610 A1, 2011 ;
Location in patent: Page/Page column 88 ;
WO 2011/059610 A1
反应条件
cesium fluoride in dimethyl sulfoxide T=140°C; 0.666667 h;
参考文献
CHUGAI SEIYAKU KABUSHIKI KAISHA; Sakai, Toshiyuki
Patent: EP1982982 A1, 2008 ;
Location in patent: Page/Page column 197-198 ;
反应条件
cesium fluoride in water; dimethyl sulfoxide
参考文献
Chugai Seiyaku Kabushiki Kaisha; Sakai, Toshiyuki
Patent: EP2172198 A1, 2010 ;
反应条件
nitric acid in sulfuric acid; water
反应条件
1: chromium(VI) oxide; sulfuric acid; acetic acid / water / 2 h / 95 °C / Inert atmosphere 2: sulfuric acid / 1 h / 70 °C / Inert atmosphere View Scheme
参考文献
WO2011/59610 A1, ;
WO 2011/059610 A1
反应条件
1: With diisobutylaluminium hydride in toluene T=-78 - 0°C; 1 h; 2: With water; Potassium sodium tartrate in methanol; toluene T=-78 - 20°C; 1 h;
参考文献
Chugai Seiyaku Kabushiki Kaisha; Sakai, Toshiyuki
Patent: EP2172198 A1, 2010 ;
反应条件
ammonium chloride; zinc in methanol T=0 - 20°C; 1.16667 h;
参考文献
NOVARTIS AG; MADERA, Ann Marie; POON, Daniel; SMITH, Aaron
Patent: WO2011/161216 A1, 2011 ;
Location in patent: Page/Page column 30 ;
WO 2011/161216 A1
