1: 55 percent / NaOMe / 2 h 2: 55 percent / sodium hypochlorite, 1.5 N NaOH / 2.5 h / 75 °C View Scheme

1: 55 percent / NaOMe / 2 h 2: 55 percent / sodium hypochlorite, 1.5 N NaOH / 2.5 h / 75 °C 3: 72 percent / 1.5 N NaOH / 2.5 h / 100 °C View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '506007', constants.ctx, '0')">acetic acid</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '969212', constants.ctx, '0')">benzene</a> <br />10&nbsp;h;&nbsp;&nbsp;Heating;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 44 percent / dioxane / 24 h / Ambient temperature<br />2: 2.) sodium methoxide / 1.) anisole, 90 deg C, 1.5 h, 2.) 140 deg C, 35 min<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: hexamethyldisilazane / 1 h / Heating<br />2: trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / 2.5 h / Ambient temperature<br />3: 63 percent / acetic acid / benzene / 10 h / Heating<br /> <br /> &nbsp;

Stage #1: <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '508906', constants.ctx, '0')">DBU</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">DMFA</a> <br />T=0 - 20&deg;C;&nbsp;0.333333&nbsp;h;&nbsp;<br />Stage #2: <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1868911', constants.ctx, '0')">trimethylsilyl trifluoromethanesulfonate</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">DMFA</a> <br />T=0 - 60&deg;C;&nbsp;1&nbsp;h;&nbsp;<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1209232', constants.ctx, '0')">chloro-trimethyl-silane</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1812100', constants.ctx, '0')">trifluorormethanesulfonic acid</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '635752', constants.ctx, '0')">1,1,1,3,3,3-hexamethyl-disilazane</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '741857', constants.ctx, '0')">acetonitrile</a> <br />T=0&deg;C;&nbsp;0.583333&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / 2.5 h<br />2: 2.) sodium methoxide / 1.) anisole, 90 deg C, 1.5 h, 2.) 140 deg C, 35 min<br /> <br /> &nbsp;