1-(4-甲氧基苯基)哌啶-4-酮合成路线 （共 8 条）
反应条件
1: 84 percent / HCl salt of hydroxylamine; potassium carbonate / ethanol; H2O / Heating View Scheme
参考文献
Willemse; Piet; Warman; Hartl; Verhoeven; Brouwer
Journal of the American Chemical Society, 2000 , vol. 122, # 15 p. 3721 - 3730
反应条件
sodium carbonate in methanol
1.5 h; Heating;
参考文献
Scherer, T.; Hielkema, W.; Krijnen, B.; Hermant, R. M.; Eijckelhoff, C.; et al.
Recueil des Travaux Chimiques des Pays-Bas, 1993 , vol. 112, # 10 p. 535 - 548
反应条件
hydrogenchloride
T=100°C;
参考文献
Schoen, Uwe; Messinger, Josef; Buckendahl; Prabhu; Konda
Tetrahedron Letters, 2007 , vol. 48, # 14 p. 2519 - 2525
反应条件
1: 97 percent / NaO-t-Bu; X-Phos / Pd(OAc)2 / toluene; 2-methyl-propan-2-ol / 10 h / 120 °C
2: 74 percent / HCl / 100 °C
View Scheme
参考文献
Schoen, Uwe; Messinger, Josef; Buckendahl; Prabhu; Konda
Tetrahedron Letters, 2007 , vol. 48, # 14 p. 2519 - 2525
反应条件
1: 97 percent / NaO-t-Bu; X-Phos / Pd(OAc)2 / toluene; 2-methyl-propan-2-ol / 10 h / 120 °C
2: 74 percent / HCl / 100 °C
View Scheme
参考文献
Schoen, Uwe; Messinger, Josef; Buckendahl; Prabhu; Konda
Tetrahedron Letters, 2007 , vol. 48, # 14 p. 2519 - 2525
反应条件
sodium hydroxide
2 h; Heating;
参考文献
Maag, Hans; Locher, Rita; Daly, John J.; Kompis, Ivan
Helvetica Chimica Acta, 1986 , vol. 69, p. 887 - 897
反应条件
1: 85 percent / NaOEt / xylene / 2 h / 110 °C
2: 71 percent / 1N NaOH / 2 h / Heating
View Scheme
参考文献
Maag, Hans; Locher, Rita; Daly, John J.; Kompis, Ivan
Helvetica Chimica Acta, 1986 , vol. 69, p. 887 - 897
反应条件
1: 80 percent / CuCl / acetic acid / 19 h / Heating
2: 85 percent / NaOEt / xylene / 2 h / 110 °C
3: 71 percent / 1N NaOH / 2 h / Heating
View Scheme
参考文献
Maag, Hans; Locher, Rita; Daly, John J.; Kompis, Ivan
Helvetica Chimica Acta, 1986 , vol. 69, p. 887 - 897
