1.1: iodine; magnesium / tetrahydrofuran / 25 - 50 °C 1.2: 40 - 50 °C 1.3: 0.25 h / 0 - 30 °C 2.1: toluene-4-sulfonic acid; 2,2'-azo-bisisobutyronitrile; N-bromosuccinmide / chloroform / 4 h / Reflux View Scheme

1: cyclopropyl bromide With iodine; magnesium in tetrahydrofuran T=25 - 50°C; 2: 2-(2-fluorophenyl)-N-methoxy-N-methylacetamide in tetrahydrofuran T=40 - 50°C; 3: With hydrogenchloride in tetrahydrofuran; water T=0 - 30°C; 0.25 h;

1.1: iodine; magnesium / tetrahydrofuran / 25 - 50 °C 1.2: 40 - 50 °C 1.3: 0.25 h / 0 - 30 °C 2.1: toluene-4-sulfonic acid; 2,2'-azo-bisisobutyronitrile; N-bromosuccinmide / chloroform / 4 h / Reflux 3.1: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C 4.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C 4.2: 1 h / -78 °C 4.3: 1 h / -60 - 0 °C 5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C View Scheme

1.1: iodine; magnesium / tetrahydrofuran / 25 - 50 °C 1.2: 40 - 50 °C 1.3: 0.25 h / 0 - 30 °C 2.1: toluene-4-sulfonic acid; 2,2'-azo-bisisobutyronitrile; N-bromosuccinmide / chloroform / 4 h / Reflux 3.1: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C 4.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C 4.2: 1 h / -78 °C 4.3: 1 h / -60 - 0 °C View Scheme

triethylamine; benzotriazol-1-ol; dicyclohexyl-carbodiimide in dichloromethane T=0 - 5°C; 6 h;

1: O,N-dimethyl-hydroxylamine hydrochloride With triethylamine in dichloromethane T=0 - 5°C; 0.25 h; 2: 2-(2-fluorophenyl)acetic acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide in dichloromethane T=0 - 5°C; 6 h;