[5-环丙基-3-(2,6-二氯苯基)-4-异噁唑基]甲醇合成路线 （共 7 条）
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran; toluene
T=0 - 20°C; 5.5 h;
2: With water; Potassium sodium tartrate in tetrahydrofuran; toluene
参考文献
SmithKline Beecham Corporation
Patent: US2008/96921 A1, 2008 ;
Location in patent: Page/Page column 48 ;
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran; toluene
2 h;
2: With hydrogenchloride; sodium hydroxide; water in tetrahydrofuran; toluene
参考文献
ELI LILLY AND COMPANY
Patent: WO2009/12125 A1, 2009 ;
Location in patent: Page/Page column 23 ;
反应条件
1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 24 h / 90 °C
2: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 20 °C
3: triethylamine / 20 °C
4: diisobutylaluminium hydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
PHENEX PHARMACEUTICALS AG; KREMOSER, Claus; ABEL, Ulrich; STEENECK, Christoph; KINZEL, Olaf
Patent: WO2011/20615 A1, 2011 ;
反应条件
1: triethylamine / 20 °C
2: diisobutylaluminium hydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Phenex Pharmaceuticals AG
Patent: EP2289883 A1, 2011 ;
EP 2289883 A1
反应条件
1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C
2: triethylamine / 20 °C
3: diisobutylaluminium hydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Phenex Pharmaceuticals AG
Patent: EP2289883 A1, 2011 ;
EP 2289883 A1
反应条件
1: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 20 °C
2: triethylamine / 20 °C
3: diisobutylaluminium hydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
PHENEX PHARMACEUTICALS AG; KREMOSER, Claus; ABEL, Ulrich; STEENECK, Christoph; KINZEL, Olaf
Patent: WO2011/20615 A1, 2011 ;
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane
T=20°C; 2 h; Product distribution / selectivity;
参考文献
ELI LILLY AND COMPANY
Patent: WO2009/12125 A1, 2009 ;
Location in patent: Page/Page column 58; 70 ;
