1-N-Boc-4-(4-氯苯基)哌啶合成路线 （共 6 条）
反应条件
trifluoroacetic acid in dichloromethane T=20°C;
参考文献
3-V BIOSCIENCES, INC.; OSLOB, Johan D.; MCDOWELL, Robert S.; JOHNSON, Russell; YANG, Hanbiao; EVANCHIK, Marc; ZAHARIA, Cristiana A.; CAI, Haiying; HU, Lily W.
Patent: WO2014/8197 A1, 2014 ;
Location in patent: Page/Page column 113 ;
反应条件
hydrogen in methanol
T=20°C; Inert atmosphere;
参考文献
3-V BIOSCIENCES, INC.; OSLOB, Johan D.; MCDOWELL, Robert S.; JOHNSON, Russell; YANG, Hanbiao; EVANCHIK, Marc; ZAHARIA, Cristiana A.; CAI, Haiying; HU, Lily W.
Patent: WO2014/8197 A1, 2014 ;
Location in patent: Page/Page column 112 ;
反应条件
caesium carbonate in 1,4-dioxane
T=110°C; 18 h; Inert atmosphereSchlenk technique;
参考文献
Allwood, Daniel M.; Blakemore, David C.; Brown, Alan D.; Ley, Steven V.
Journal of Organic Chemistry, 2014 , vol. 79, # 1 p. 328 - 338
反应条件
1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / |Inert atmosphere
1.2: 1 h / -78 °C / |Inert atmosphere
2.1: pyridine; trichlorophosphate / 20 °C
3.1: hydrogen / methanol / 20 °C / |Inert atmosphere
View Scheme
参考文献
3-V BIOSCIENCES, INC.; OSLOB, Johan D.; MCDOWELL, Robert S.; JOHNSON, Russell; YANG, Hanbiao; EVANCHIK, Marc; ZAHARIA, Cristiana A.; CAI, Haiying; HU, Lily W.
Patent: WO2014/8197 A1, 2014 ;
反应条件
1: pyridine; trichlorophosphate / 20 °C
2: hydrogen / methanol / 20 °C / |Inert atmosphere
View Scheme
参考文献
3-V BIOSCIENCES, INC.; OSLOB, Johan D.; MCDOWELL, Robert S.; JOHNSON, Russell; YANG, Hanbiao; EVANCHIK, Marc; ZAHARIA, Cristiana A.; CAI, Haiying; HU, Lily W.
Patent: WO2014/8197 A1, 2014 ;
反应条件
1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / |Inert atmosphere
1.2: 1 h / -78 °C / |Inert atmosphere
2.1: pyridine; trichlorophosphate / 20 °C
3.1: hydrogen / methanol / 20 °C / |Inert atmosphere
View Scheme
参考文献
3-V BIOSCIENCES, INC.; OSLOB, Johan D.; MCDOWELL, Robert S.; JOHNSON, Russell; YANG, Hanbiao; EVANCHIK, Marc; ZAHARIA, Cristiana A.; CAI, Haiying; HU, Lily W.
Patent: WO2014/8197 A1, 2014 ;
