5-氯-3-甲基-1-苯基吡唑-4-甲醛合成路线 （共 23 条）
反应条件
hydrazine hydrate T=180°C; im Rohr;
参考文献
Rojahn; Fahr
Justus Liebigs Annalen der Chemie, 1923 , vol. 434, p. 260
参考文献
Rojahn; Fahr
Justus Liebigs Annalen der Chemie, 1923 , vol. 434, p. 260
反应条件
1: 98 percent / NH2OH*HCl, CH3COONa / ethanol; H2O / 0.5 h / 70 °C 2: 95 percent / (CH3CO)2O / 3 h / 140 - 150 °C View Scheme
参考文献
Haider, Norbert; Farghaly, Abdel-Rahman; Al-Mekhlafi, Nabil; El-Kashef, Hussein
Journal of Chemical Research, 2005 , # 12 p. 761 - 765
反应条件
sodium sulfide in dimethyl sulfoxide T=60 - 70°C; 3.5 h;
参考文献
Nivorozhkin, Alexander L.; Toftlund, Hans; Nielsen, Max
Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1994 , # 3 p. 361 - 368
反应条件
1: 87 percent / ammonium acetate, piperidine / ethanol / 4 h / Heating 2: ethyl cyanoacetate / ethanol / 8 h / Heating View Scheme
参考文献
Shiba; Harb; Hassan; El-Kassaby; Abou-El-Regal
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996 , vol. 35, # 5 p. 426 - 430
反应条件
potassium hydroxide in methanol; water 4 h; Heating;
参考文献
Koshelev,Yu.N. et al.
Journal of Organic Chemistry USSR (English Translation), 1972 , vol. 8, p. 1789 - 1793
Zhurnal Organicheskoi Khimii, 1972 , vol. 8, # 8 p. 1750 - 1754
反应条件
1: 95 percent / methanol / 1 h / 50 °C 2: 95 percent / NaOCH3 / methanol / 0.5 h / 60 - 70 °C 3: sodium hydroxide / methanol / 1.5 h / Heating View Scheme
参考文献
Ahluwalia, Vinod K.; Dahiya, Aruna; Bala, Madhu
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996 , vol. 35, # 7 p. 715 - 717
反应条件
1: 92 percent / NaN3; tetrabutylammonium bromide / dimethylsulfoxide / 24 h / 20 °C 2: 91 percent / Fe; aq. NH4Cl / ethyl acetate / 4 h / 20 °C 3: 92 percent / NH2OH*HCl; pyridine / ethanol / 2 h / 20 °C 4: 65 percent / POCl3 / 0.5 h / Heating View Scheme
参考文献
Barreiro, Eliezer J.; Camara, Celso A.; Verli, Hugo; Brazil-Mas, Leonora; Castro, Newton G.; Cintra, Wagner M.; Aracava, Yasco; Rodrigues, Carlos R.; Fraga, Carlos A. M.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 7 p. 1144 - 1152
反应条件
sodium hydroxide in tert-butyl alcohol T=25°C; electrochemical oxidation at nickel hydroxide anode;
参考文献
Abdel-Azzem; Zahran
Bulletin of the Chemical Society of Japan, 1994 , vol. 67, # 7 p. 1879 - 1880
反应条件
sodium borohydride in methanol; water
参考文献
E. R. Squibb and Sons, Inc.
Patent: US4248881 A1, 1981 ;
