(3,5-二甲氧基苯基)(4-甲氧基苯基)-甲酮合成路线 (共 10 条)
反应条件
aluminium trichloride in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; hexane; dichloromethane; ethyl acetate; methoxybenzene
参考文献
Celgene Corporation
Patent: US2005/107339 A1, 2005 ;
反应条件
1.1: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C
1.2: 80.9 percent / tetrahydrofuran / 6 h
2.1: 77.7 percent / PDC; molecular sieves 4 A / CH2Cl2 / 24 h
View Scheme
参考文献
Pettit, George R.; Grealish, Matthew P.; Jung, M. Katherine; Hamel, Ernest; Pettit, Robin K.; Chapuis, J.-Charles; Schmidt, Jean M.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 12 p. 2534 - 2542
反应条件
1.1: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C
1.2: 80.9 percent / tetrahydrofuran / 6 h
2.1: 77.7 percent / PDC; molecular sieves 4 A / CH2Cl2 / 24 h
View Scheme
参考文献
Pettit, George R.; Grealish, Matthew P.; Jung, M. Katherine; Hamel, Ernest; Pettit, Robin K.; Chapuis, J.-Charles; Schmidt, Jean M.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 12 p. 2534 - 2542
反应条件
carbon disulfide; aluminium trichloride
参考文献
Mauthner
Journal fuer Praktische Chemie (Leipzig), 1913 , vol. <2> 87, p. 415
参考文献
James,N.F. et al.
Journal of the Chemical Society, 1963 , p. 1356 - 1363
反应条件
1: KMnO4
2: Cu / quinoline
View Scheme
参考文献
James,N.F. et al.
Journal of the Chemical Society, 1963 , p. 1356 - 1363
反应条件
1: aq. NaOH
2: KMnO4
3: Cu / quinoline
View Scheme
参考文献
James,N.F. et al.
Journal of the Chemical Society, 1963 , p. 1356 - 1363
反应条件
potassium permanganate
参考文献
James,N.F. et al.
Journal of the Chemical Society, 1963 , p. 1356 - 1363
反应条件
1: phosphorus pentachloride
2: carbon disulfide; aluminium chloride
View Scheme
参考文献
Mauthner
Journal fuer Praktische Chemie (Leipzig), 1913 , vol. <2> 87, p. 415
参考文献
Mauthner
Journal fuer Praktische Chemie (Leipzig), 1913 , vol. <2> 87, p. 415