反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 1.5 h / -10 - -8 °C / Inert atmosphere; Large scale reaction
1.2: 1.5 h / -10 - -7 °C
2.1: ammonia / tetrahydrofuran / 41 h / 45 - 50 °C / Large scale reaction
3.1: 10 Pd(OH)2 on C; hydrogen / ethanol / 3 h / 20 °C / 5925.59 Torr / Large scale reaction
4.1: acetic acid / 100 °C / Large scale reaction
View Scheme
参考文献
Adam, Fiona M.; Bish, Gerwyn; Calo, Frederick; Carr, Christopher L.; Castro, Nieves; Hay, Duncan; Hodgson, Paul B.; Jones, Peter; Knight, Craig J.; Paradowski, Michael; Parsons, Gemma C.; Proctor, Katie J. W.; Pryde, David C.; Rota, Filippo; Smith, Mya C.; Smith, Nicholas; Tran, Thien-Duc; Hitchin, James; Dixon, Rachel
Organic Process Research and Development, 2011 , vol. 15, # 4 p. 788 - 796
