(4-(二氟甲基)噻唑-2-基)氨基甲酸叔丁酯合成路线 （共 4 条）
反应条件
1: With diethylamino-sulfur trifluoride in dichloromethane
T=20°C; 16 h;
2: With sodium hydrogencarbonate in dichloromethane; water
参考文献
Jaeschke, Georg; Spooren, Will; Vieira, Eric
Patent: US2007/197553 A1, 2007 ;
Location in patent: Page/Page column 28 ;
US 20070197553 A1
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -78 °C
2: Dess-Martin periodane / dichloromethane / 2 h / 20 °C
3: diethylamino-sulfur trifluoride / ethanol; dichloromethane / 20 °C
View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GUO, Lei; HU, Taishan; HU, Yimin; KOCER, Buelent; LIN, Xianfeng; LIU, Haixia; MAYWEG, Alexander V.; QIU, Zongxing; SHEN, Hong; TANG, Guozhi; WANG, Lisha; WU, Guolong; YAN, Shixiang; ZHANG, Weixing; ZHOU, Mingwei; ZHU, Wei
Patent: WO2014/37480 A1, 2014 ;
反应条件
1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C
2: diethylamino-sulfur trifluoride / ethanol; dichloromethane / 20 °C
View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GUO, Lei; HU, Taishan; HU, Yimin; KOCER, Buelent; LIN, Xianfeng; LIU, Haixia; MAYWEG, Alexander V.; QIU, Zongxing; SHEN, Hong; TANG, Guozhi; WANG, Lisha; WU, Guolong; YAN, Shixiang; ZHANG, Weixing; ZHOU, Mingwei; ZHU, Wei
Patent: WO2014/37480 A1, 2014 ;
反应条件
1: With hydrogenchloride in ethanol; ethyl acetate
T=20°C; 2 h;
2: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
Jaeschke, Georg; Spooren, Will; Vieira, Eric
Patent: US2007/197553 A1, 2007 ;
Location in patent: Page/Page column 28 ;
US 20070197553 A1
