triphenylphosphine in dichloromethane; acetonitrile

1: 1.) triethylamine; 2.) 1 N HCl / 1.) DMF, r.t. 2 h; 2.) methanol, 0 deg C, 15 min 2: 91 percent / H2 / 10 percent Pd-C / methanol 3: 1.) Ph3P, PySSPy; 2.) triethylamine, methyl iodide / 1.) acetonitrile, 80 deg C, 4 h; 2.) methylene chloride, 0 deg C, 20 min View Scheme

1: 85 percent / 1 n NaOH / methanol / 0.67 h / 0 - 25 °C 2: 1.) triethylamine; 2.) 1 N HCl / 1.) DMF, r.t. 2 h; 2.) methanol, 0 deg C, 15 min 3: 91 percent / H2 / 10 percent Pd-C / methanol 4: 1.) Ph3P, PySSPy; 2.) triethylamine, methyl iodide / 1.) acetonitrile, 80 deg C, 4 h; 2.) methylene chloride, 0 deg C, 20 min View Scheme

1: 1.) triethylamine; 2.) 1 N HCl / 1.) DMF, r.t. 2 h; 2.) methanol, 0 deg C, 15 min 2: 91 percent / H2 / 10 percent Pd-C / methanol 3: 1.) Ph3P, PySSPy; 2.) triethylamine, methyl iodide / 1.) acetonitrile, 80 deg C, 4 h; 2.) methylene chloride, 0 deg C, 20 min View Scheme

1: 91 percent / H2 / 10 percent Pd-C / methanol 2: 1.) Ph3P, PySSPy; 2.) triethylamine, methyl iodide / 1.) acetonitrile, 80 deg C, 4 h; 2.) methylene chloride, 0 deg C, 20 min View Scheme

PySSpy; triethylamine; triphenylphosphine; methyl iodide 1.) acetonitrile, 80 deg C, 4 h; 2.) methylene chloride, 0 deg C, 20 min; Yield given. Multistep reaction;