N-(6-氯咪唑并[1,2-b]吡嗪-2-基)-2,2,2-三氟乙酰胺合成路线 (共 3 条)
反应条件
methanol; water; potassium carbonate in tetrahydrofuran 8 h; Heating / reflux; Product distribution / selectivity;
参考文献
US2009/163489 A1, ;
Page/Page column 20 ;
US 20090163489 A1
反应条件
1: in dichloromethane
T=50°C; 3 h;
2: With sodium hydrogencarbonate in water
参考文献
MERCK SERONO S.A.; SWINNEN, Dominique; JORAND-LEBRUN, Catherine; GRIPPI-VALLOTTON, Tania; GERBER, Patrick; GONZALEZ, Jerome; SHAW, Jeffrey; JEYAPRAKASHNARAYANAN, Seenisamy
Patent: WO2010/100144 A1, 2010 ;
Location in patent: Page/Page column 163 ;
WO 2010/100144 A1
反应条件
in dichloromethane
3 h; Heating / reflux;
参考文献
Booker, Shon; Kim, Tae-Seong; Liao, Hongyu; Liu, Longbin; Norman, Mark H.; Peterson, Emily Anne; Stec, Markian; Tamayo, Nuria A.
Patent: US2009/163489 A1, 2009 ;
Location in patent: Page/Page column 20 ;
US 20090163489 A1