6-溴-[1,2,4]噻唑并[1,5-a]吡啶-2-胺合成路线 （共 4 条）
反应条件
hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine in methanol; ethanol T=20 - 70°C;
参考文献
MERCK SERONO S.A.; SWINNEN, Dominique; JORAND-LEBRUN, Catherine; GRIPPI-VALLOTTON, Tania; GERBER, Patrick; GONZALEZ, Jerome; SHAW, Jeffrey; JEYAPRAKASHNARAYANAN, Seenisamy
Patent: WO2010/100144 A1, 2010 ;
Location in patent: Page/Page column 102-103 ;
WO 2010/100144 A1
反应条件
1: hydroxylamine hydrochloride With N-ethyl-N,N-diisopropylamine in methanol; ethanol T=20°C; 1 h; 2: ethyl [(5-bromopyridin-2-yl)carbamothioyl]carbamate in methanol; ethanol Reflux;
参考文献
Shionogi and Co., Ltd.
Patent: EP2426135 A1, 2012 ;
Location in patent: Page/Page column 113 ;
反应条件
1: 1,4-dioxane / 2 h / 20 °C 2: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / ethanol; methanol / 2 h / 20 - 60 °C View Scheme
参考文献
WO2011/63908 A1, ;
WO 2011/063908 A1
WO2012/143329 A1, ;
WO 2012/143329 A1
反应条件
1: With sulfuric acid; sodium nitrite in acetic acid T=20°C; 1 h; 2: With hydrogen bromide; copper(I) bromide in acetic acid T=0 - 20°C; 2 h; 3: With sodium carbonate in water; acetic acid pH=8;
参考文献
PROZYMEX A/S; PEDERSEN, John; LAURITZEN, Conni
Patent: WO2012/130299 A1, 2012 ;
Location in patent: Page/Page column 130 ;
WO 2012/130299 A1
