5-溴-3-(二氟甲氧基)吡啶-2-胺合成路线 （共 3 条）
反应条件
1: With bromine; acetic acid T=20°C; 2 h; 2: With water; sodium hydrogencarbonate in ethyl acetate
参考文献
PFIZER INC.
Patent: WO2009/16460 A2, 2009 ;
Location in patent: Page/Page column 56 ;
WO 2009/016460 A2
反应条件
1: sodium hydroxide / N,N-dimethyl-formamide / 111 h / 55 °C 2: copper(I) oxide; ammonium hydroxide / water; 2-methoxy-ethanol / 23 h / 100 °C 3: N-bromosuccinmide / acetonitrile / 0.17 h / 0 °C View Scheme
反应条件
1: copper(I) oxide; ammonium hydroxide / water; 2-methoxy-ethanol / 23 h / 100 °C 2: N-bromosuccinmide / acetonitrile / 0.17 h / 0 °C View Scheme
