3-甲氧基-5-(4,4,5,5-四甲基-1,3,2-二氧硼戊环-2-基)-2-氨基吡啶合成路线 （共 3 条）
反应条件
potassium acetate; tris-(dibenzylideneacetone)dipalladium(0); tri-cyclo-hexyl-phosphine in 1,4-dioxane
T=110°C; 6 h; Inert atmosphere;
参考文献
Huang, Zilin; Jin, Jeff; Machajewski, Timothy; Antonios-McCrea, William R.; McKenna, Maureen; Poon, Daniel; Renhowe, Paul A.; Sendzik, Martin; Shafer, Cynthia; Smith, Aaron; Xu, Yongjin; Zhang, Qiong; Chen, Zheng
Patent: US2013/210818 A1, 2013 ;
Location in patent: Paragraph 0382 ;
反应条件
1.1: palladium 10 on activated carbon; hydrogen / ethyl acetate; methanol / 3 h
2.1: bromine; sulfuric acid; acetic acid / water / 2 h / 3 - 5 °C
2.2: pH 8 / |Cooling with ice
3.1: potassium acetate; tris-(dibenzylideneacetone)dipalladium(0); tri-cyclo-hexyl-phosphine / 1,4-dioxane / 6 h / 110 °C / |Inert atmosphere
View Scheme
参考文献
Huang, Zilin; Jin, Jeff; Machajewski, Timothy; Antonios-McCrea, William R.; McKenna, Maureen; Poon, Daniel; Renhowe, Paul A.; Sendzik, Martin; Shafer, Cynthia; Smith, Aaron; Xu, Yongjin; Zhang, Qiong; Chen, Zheng
Patent: US2013/210818 A1, 2013 ;
反应条件
1.1: bromine; sulfuric acid; acetic acid / water / 2 h / 3 - 5 °C
1.2: pH 8 / |Cooling with ice
2.1: potassium acetate; tris-(dibenzylideneacetone)dipalladium(0); tri-cyclo-hexyl-phosphine / 1,4-dioxane / 6 h / 110 °C / |Inert atmosphere
View Scheme
参考文献
Huang, Zilin; Jin, Jeff; Machajewski, Timothy; Antonios-McCrea, William R.; McKenna, Maureen; Poon, Daniel; Renhowe, Paul A.; Sendzik, Martin; Shafer, Cynthia; Smith, Aaron; Xu, Yongjin; Zhang, Qiong; Chen, Zheng
Patent: US2013/210818 A1, 2013 ;
