citric acid in dichloromethane; water T=20°C; 1.5 h;

1: With 2,3-dihydroxybutanedioic acid in ethyl acetate 2: With sodium hydroxide in water Product distribution / selectivity;

1: (R-(E))-1-(((1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid cyclooctylammonium salt With water; 2,3-dihydroxybutanedioic acid in ethyl acetate T=20°C; 0.5 h; 2: sodium hydroxide in water; ethyl acetate Product distribution / selectivity;

1: (R-(E))-1-(((1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid cyclooctylammonium salt With water; citric acid in dichloromethane T=20°C; 0.5 h; 2: sodium hydroxide in dichloromethane; water pH=8.65; Product distribution / selectivity;