[4-[(6-溴己基)氧基]丁基]苯合成路线 （共 8 条）
反应条件
triethylamine; sodium iodide
参考文献
Liu, Juntao; Zhou, Di; Jia, Xian; Huang, Ling; Li, Xingshu; Chan, Albert S.C.
Tetrahedron Asymmetry, 2008 , vol. 19, # 15 p. 1824 - 1828
反应条件
1: NaN3 / dimethylformamide 2: lithium aluminum hydride 3: 1.) mol. sieves; 2.) NaBH4 / 2.) ethanol View Scheme
参考文献
Hett, Robert; Stare, Ragnar; Helquist, Paul
Tetrahedron Letters, 1994 , vol. 35, # 50 p. 9375 - 9378
反应条件
1: 70 percent / Et3N, NaI / dimethylsulfoxide / 17 h / Ambient temperature 2: 71 percent / acetonitrile / 1 h / Heating; other solvent 3: NaBH4 / methanol / 36 h / Ambient temperature 4: 0.21 g / H2 / Pd/C / methanol / 10 h View Scheme
参考文献
CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash, Dhar; SHAH, Niraj, Shyamlal
Patent: WO2012/32546 A2, 2012 ;
反应条件
1: 4-phenylbutyl alcohol With sodium hydride in tetrahydrofuran
T=0 - 20°C;
2: 1,6-dibromo-n-hexane With tetrabutylammomium bromide in tetrahydrofuran
T=20°C; 16 h;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2010/9950 A1, 2010 ;
Location in patent: Page/Page column 20 ;
US 20100009950 A1
参考文献
Boehringer Ingelheim Pharma GmbH and Co. KG
Patent: US2003/171620 A1, 2003 ;
反应条件
tetrabutylammomium bromide
参考文献
CORUS PHARMA, INC.
Patent: WO2006/138212 A1, 2006 ;
Location in patent: Page/Page column 38 ;
反应条件
1: 70 percent / Et3N, NaI / dimethylsulfoxide / 17 h / Ambient temperature
2: 71 percent / acetonitrile / 1 h / Heating; other solvent
3: NaBH4 / methanol / 36 h / Ambient temperature
View Scheme
参考文献
Rong, Yajing; Ruoho, Arnold E.
Synthetic Communications, 1999 , vol. 29, # 12 p. 2155 - 2162
反应条件
1: 90 percent / NaN3 / dimethylformamide / 6 h / 120 °C
2: 80 percent / LiAlH4 / tetrahydrofuran / 12 h / Ambient temperature
View Scheme
参考文献
Hett, Robert; Stare, Ragnar; Helquist, Paul
Tetrahedron Letters, 1994 , vol. 35, # 50 p. 9375 - 9378
