5-三氟甲基-3-吡啶硼酸合成路线 （共 4 条）
反应条件
1: With n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran; hexane T=-78°C; 3.5 h; Inert atmosphere; 2: With water in tetrahydrofuran; hexane T=-10°C;
参考文献
Clapham, Kate M.; Batsanov, Andrei S.; Bryce, Martin R.; Tarbit, Brian
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 10 p. 2155 - 2161
反应条件
potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in 1,4-dioxane; water T=90°C; 21 h; Inert atmosphere;
参考文献
WO2012/3283 A1, ;
Page/Page column 239 ;
WO 2012/003283 A1
反应条件
n-butyllithium; acetic acid in tetrahydrofuran; hexane
参考文献
Jacobus Pharmaceutical Company, Inc.; Heffernan, Gavin David; Jacobus, David Penman; Saionz, Kurt William; Schiehser, Guy Alan; Shieh, Hong-Ming; Zhao, Wenyi
Patent: US2014/135320 A1, 2014 ;
Location in patent: Paragraph 0224; 0225 ;
反应条件
CH3CH2CH2CH2Li in tetrahydrofuran; hexane addn. of hexane soln. of butyllithium to mixt. of boron compd. and pyridine deriv. in THF at -78°C under Ar, stirring at -78°C for3.5 h, warming to -10°C; addn. of deionized water, evapn., addn. of NaOH to pH 10, washing with diethyl ether, addn. of acetic acid to pH 5, extn. (ethyl acetate), evapn., NMR;
参考文献
Clapham, Kate M.; Batsanov, Andrei S.; Bryce, Martin R.; Tarbit, Brian
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 10 p. 2155 - 2161
