反应条件
1: 4-bromo-2-pyridinecarboxylic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=20°C; 0.0833333 h;
2: pyrrolidine in N,N-dimethyl-formamide
0.25 h;
参考文献
UCB PHARMA S.A.; BUeRLI, Roland; HAUGHAN, Alan, Findlay; MACK, Stephen, Robert; PERRY, Benjamin, Garfield; RAPHY, Gilles; SAVILLE-STONES, Elizabeth, Anne
Patent: WO2010/52448 A2, 2010 ;
Location in patent: Page/Page column 39 ;
WO 2010/052448 A2
