2-(5-羟基-3-甲氧基吡啶-2-基)乙酸甲酯合成路线 （共 4 条）
反应条件
water; dihydrogen peroxide in dichloromethane
T=17 - 25°C; 2 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/99317 A1, 2007 ;
Location in patent: Page/Page column 110-111 ;
WO 2007/099317 A1
反应条件
1: lithium hexamethyldisilazane / tetrahydrofuran / 20 °C
2: chloro-trimethyl-silane / 4 h / 65 °C
3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 6 h / 85 °C
4: dihydrogen peroxide / dichloromethane / 1.5 h / 20 °C
View Scheme
参考文献
Ple, Patrick A.; Jung, Frederic; Ashton, Sue; Hennequin, Laurent; Laine, Romuald; Lambert-Van Der Brempt, Christine; Morgentin, Remy; Pasquet, Georges; Taylor, Sian
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3050 - 3055
反应条件
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 6 h / 85 °C
2: dihydrogen peroxide / dichloromethane / 1.5 h / 20 °C
View Scheme
参考文献
Ple, Patrick A.; Jung, Frederic; Ashton, Sue; Hennequin, Laurent; Laine, Romuald; Lambert-Van Der Brempt, Christine; Morgentin, Remy; Pasquet, Georges; Taylor, Sian
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3050 - 3055
反应条件
1: chloro-trimethyl-silane / 4 h / 65 °C
2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 6 h / 85 °C
3: dihydrogen peroxide / dichloromethane / 1.5 h / 20 °C
View Scheme
参考文献
Ple, Patrick A.; Jung, Frederic; Ashton, Sue; Hennequin, Laurent; Laine, Romuald; Lambert-Van Der Brempt, Christine; Morgentin, Remy; Pasquet, Georges; Taylor, Sian
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3050 - 3055
