缬氨酰-谷氨酰-脯氨酰-异亮氨酰-脯氨酰-酪氨酸合成路线 （共 5 条）
反应条件
hydrogen; palladium on activated charcoal in methanol; acetic acid
48 h;
参考文献
Sharan, R.; Kundu, B.; Mathur, K. B.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1991 , vol. 30, # 8 p. 728 - 731
反应条件
1: 4-methyl-morpholine; TBTU / CH2Cl2 / 0 °C
2: H2; AcOH / 10 percent Pd/C / methanol
View Scheme
参考文献
Rysz; Redlinski; Mudyna; Luciak; Kaminski
Acta Poloniae Pharmaceutica - Drug Research, 2000 , vol. 57, # SUPPL. p. 11 - 14
反应条件
1.1: 4-methyl-morpholine; TBTU / CH2Cl2 / 0 °C
2.1: TFA; anisole / CH2Cl2 / 20 °C
2.2: HCl / methanol
3.1: 4-methyl-morpholine; TBTU / CH2Cl2 / 0 °C
4.1: H2; AcOH / 10 percent Pd/C / methanol
View Scheme
参考文献
Rysz; Redlinski; Mudyna; Luciak; Kaminski
Acta Poloniae Pharmaceutica - Drug Research, 2000 , vol. 57, # SUPPL. p. 11 - 14
反应条件
1.1: TFA; anisole / CH2Cl2 / 20 °C
1.2: HCl / methanol
2.1: 4-methyl-morpholine; TBTU / CH2Cl2 / 0 °C
3.1: TFA; anisole / CH2Cl2 / 20 °C
3.2: HCl / methanol
4.1: 4-methyl-morpholine; TBTU / CH2Cl2 / 0 °C
5.1: H2; AcOH / 10 percent Pd/C / methanol
View Scheme
参考文献
Rysz; Redlinski; Mudyna; Luciak; Kaminski
Acta Poloniae Pharmaceutica - Drug Research, 2000 , vol. 57, # SUPPL. p. 11 - 14
反应条件
1.1: TFA; anisole / CH2Cl2 / 20 °C
1.2: HCl / methanol
2.1: 4-methyl-morpholine; TBTU / CH2Cl2 / 0 °C
3.1: H2; AcOH / 10 percent Pd/C / methanol
View Scheme
参考文献
Rysz; Redlinski; Mudyna; Luciak; Kaminski
Acta Poloniae Pharmaceutica - Drug Research, 2000 , vol. 57, # SUPPL. p. 11 - 14
