甲基-1-羟基-2-萘甲酸盐合成路线 （共 73 条）
反应条件
hydroxylamine hydrochloride
参考文献
Urbanski et al.
Roczniki Chemii, 1953 , vol. 27, p. 47,49, 50
Chem.Abstr., 1954 , p. 13658
参考文献
Jeanrenaud
Chemische Berichte, 1889 , vol. 22, p. 1272
反应条件
potassium hydrogencarbonate in acetone
参考文献
Riker Laboratories, Inc.
Patent: US3996280 A1, 1976 ;
反应条件
1.1: LDA / tetrahydrofuran; hexane / 1.5 h / -10 °C 1.2: 78 percent / tetrahydrofuran; hexane / 16 h / 25 °C 2.1: 63 percent / triflic anhydride / CH2Cl2 / 20 h / 0 °C View Scheme
参考文献
Griffin, Roger J.; Fontana, Gabriele; Golding, Bernard T.; Guiard, Sophie; Hardcastle, Ian R.; Leahy, Justin J. J.; Martin, Niall; Richardson, Caroline; Rigoreau, Laurent; Stockley, Martin; Smith, Graeme C. M.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 2 p. 569 - 585
反应条件
1: ethanolic sodium ethylate
2: <300
3: sodium-amalgam; aqueous NaOH-solution; ethanol / und Erwaermen des Reaktionsprodukts mit Eisen(III)-chlorid und wss. Salzsaeure
View Scheme
参考文献
Cymerman-Craig; Loder
Journal of the Chemical Society, 1955 , p. 4309,4313
反应条件
ethanol; hydrazine hydrate
参考文献
Beyer; Schulte
Chemische Berichte, 1941 , vol. 74, p. 98,103
反应条件
nitrobenzene; zinc(II) chloride
参考文献
Desai; Waravdekar
Proceedings - Indian Academy of Sciences, Section A, 1946 , # 24 p. 332,335
反应条件
potassium carbonate in acetone
12 h; Heating;
参考文献
Mahesh, V. K.; Maheshwari, Mamta; Sharma, Rakesh
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 2 p. 129 - 131
反应条件
methanol; potassium hydroxide
Destillieren des Reaktionsprodukts im Vakuum und Verseifen des bei 223-225grad unter 60 mmHg uebergehenden Methoxynaphthoesaeuremethylesters mit waessr. Kalilauge;
参考文献
Huebner
Monatshefte fuer Chemie, 1894 , vol. 15, p. 723
Full Text Show Details
Cohen; Dudley
Journal of the Chemical Society, 1910 , vol. 97, p. 1747
反应条件
1: 4-acetylmorpholine With lithium diisopropyl amide in tetrahydrofuran; hexane
T=-10°C; 1.5 h;
2: methyl 1-hydroxy-naphthalene-2-carboxylate in tetrahydrofuran; hexane
T=25°C; 16 h;
参考文献
Griffin, Roger J.; Fontana, Gabriele; Golding, Bernard T.; Guiard, Sophie; Hardcastle, Ian R.; Leahy, Justin J. J.; Martin, Niall; Richardson, Caroline; Rigoreau, Laurent; Stockley, Martin; Smith, Graeme C. M.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 2 p. 569 - 585
