1: With sodium hydroxide; water in methanol T=50°C; 3 h; 2: With hydrogenchloride in water pH=6;

1: 1-methyl-piperazine With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) in toluene 0.5 h; Heating / reflux; 2: methyl 4-bromo-3-fluoro-benzoate in toluene T=105°C; 18 h;