4-氰基-2(1H)-吡啶酮合成路线 （共 5 条）
反应条件
sulfuric acid; sodium nitrite in water T=0°C; 0.5 h; Reflux;
参考文献
AKAAL PHARMA PTY LTD; GROBELNY, Damian W; GILL, Gurmit S
Patent: WO2014/63199 A1, 2014 ;
Location in patent: Page/Page column 59 ;
反应条件
sodium hydroxide in water T=27°C; pH=7.0; 44 h; Mediumfermentation; Product distribution / selectivity;
参考文献
EP1801102 A1, ;
Page/Page column 10-11 ;
反应条件
trifluoroacetic anhydride T=120°C; 144 h;
参考文献
Wang, Li-Hsing; Zipse, Hendrik
Liebigs Annales, 1996 , # 10 p. 1501 - 1509
反应条件
1: pyridine / 0.5 h / |Reflux 2: sodium nitrite; sulfuric acid / water / 0.5 h / 0 °C / |Reflux View Scheme
反应条件
1: iodine; acetic acid; sodium periodate; sulfuric acid / water / 4 h / 80 °C 2: pyridine / 0.5 h / |Reflux 3: sodium nitrite; sulfuric acid / water / 0.5 h / 0 °C / |Reflux View Scheme
