6-溴-2-氯-3-氯甲基喹啉合成路线 （共 2 条）
反应条件
1.1: trichlorophosphate / Cooling with ice; Sealed tube; Inert atmosphere
1.2: 48.5 h / 75 °C
1.3: Cooling with ice
2.1: ethanol; sodium tetrahydroborate / 0.67 h / 0 - 20 °C
3.1: thionyl chloride / dichloromethane / 2.5 h / 20 °C
View Scheme
参考文献
AMGEN INC.; PARAS, Nick A,; CHENG, Yuan; POWERS, Timothy; BROWN, James; HITCHCOCK, Stephen; JUDD, Ted; LOPEZ, Patricia; XUE, Qiufen; YANG, Bryant
Patent: WO2011/63272 A1, 2011 ;
WO 2011/063272 A1
反应条件
1: ethanol; sodium tetrahydroborate / 0.67 h / 0 - 20 °C
2: thionyl chloride / dichloromethane / 2.5 h / 20 °C
View Scheme
参考文献
AMGEN INC.; PARAS, Nick A,; CHENG, Yuan; POWERS, Timothy; BROWN, James; HITCHCOCK, Stephen; JUDD, Ted; LOPEZ, Patricia; XUE, Qiufen; YANG, Bryant
Patent: WO2011/63272 A1, 2011 ;
WO 2011/063272 A1
