2-氯-3-氯甲基-8-甲基喹啉合成路线 （共 4 条）
反应条件
thionyl chloride in chloroform
T=20°C; 3 h;
参考文献
EXELIXIS, INC.; LEAHY, James, William
Patent: WO2012/37204 A1, 2012 ;
Location in patent: Page/Page column 72; 73 ;
WO 2012/037204 A1
反应条件
1: methanol; sodium tetrahydroborate / 0.5 h / 20 °C
2: thionyl chloride / benzene / Reflux
View Scheme
参考文献
Kumar, Suresh; Bawa, Sandhya; Drabu, Sushma; Gupta, Himanshu; MacHwal, Lalit; Kumar, Rajiv
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 670 - 675
反应条件
triethylamine in ethanol
Reflux;
参考文献
Kumar, Suresh; Bawa, Sandhya; Drabu, Sushma; Gupta, Himanshu; MacHwal, Lalit; Kumar, Rajiv
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 670 - 675
反应条件
triethylamine in ethanol
Reflux;
参考文献
Kumar, Suresh; Bawa, Sandhya; Drabu, Sushma; Gupta, Himanshu; MacHwal, Lalit; Kumar, Rajiv
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 670 - 675
