4-[3,5-二甲基-4-(4-硝基苄氧基)苯基]-4-氧代丁酸琥珀酰亚胺酯合成路线 （共 8 条）
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane
T=20°C; 3 h;
参考文献
Gathirwa, Jeremiah W.; Maki, Toshihide
Synthetic Communications, 2013 , vol. 43, # 7 p. 1016 - 1022
反应条件
1: aq. NaOH / tetrahydrofuran / 3 h / 20 °C
2: EDAC / CH2Cl2 / 3 h / 20 °C
View Scheme
参考文献
Maki, Toshihide; Ishida, Koji
Journal of Organic Chemistry, 2007 , vol. 72, # 17 p. 6427 - 6433
反应条件
1: 95 percent / K2CO3 / dimethylformamide / 3 h / 20 °C
2: aq. NaOH / tetrahydrofuran / 3 h / 20 °C
3: EDAC / CH2Cl2 / 3 h / 20 °C
View Scheme
参考文献
Maki, Toshihide; Ishida, Koji
Journal of Organic Chemistry, 2007 , vol. 72, # 17 p. 6427 - 6433
反应条件
1: 65 percent / BBr3 / CH2Cl2 / 12 h / -5 °C
2: 95 percent / K2CO3 / dimethylformamide / 3 h / 20 °C
3: aq. NaOH / tetrahydrofuran / 3 h / 20 °C
4: EDAC / CH2Cl2 / 3 h / 20 °C
View Scheme
参考文献
Maki, Toshihide; Ishida, Koji
Journal of Organic Chemistry, 2007 , vol. 72, # 17 p. 6427 - 6433
反应条件
1: 95 percent / AlCl3 / 1,2-dichloro-ethane / 3 h / 20 °C
2: 95 percent / K2CO3 / dimethylformamide / 12 h / 20 °C
3: 65 percent / BBr3 / CH2Cl2 / 12 h / -5 °C
4: 95 percent / K2CO3 / dimethylformamide / 3 h / 20 °C
5: aq. NaOH / tetrahydrofuran / 3 h / 20 °C
6: EDAC / CH2Cl2 / 3 h / 20 °C
View Scheme
参考文献
Maki, Toshihide; Ishida, Koji
Journal of Organic Chemistry, 2007 , vol. 72, # 17 p. 6427 - 6433
反应条件
1: 95 percent / K2CO3 / dimethylformamide / 12 h / 20 °C
2: 65 percent / BBr3 / CH2Cl2 / 12 h / -5 °C
3: 95 percent / K2CO3 / dimethylformamide / 3 h / 20 °C
4: aq. NaOH / tetrahydrofuran / 3 h / 20 °C
5: EDAC / CH2Cl2 / 3 h / 20 °C
View Scheme
参考文献
Maki, Toshihide; Ishida, Koji
Journal of Organic Chemistry, 2007 , vol. 72, # 17 p. 6427 - 6433
反应条件
1: hydrogenchloride / 1,2-dichloro-benzene / 12 h / 20 °C
2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C
3: sodium hydroxide / tetrahydrofuran; water / 3 h / 20 °C
4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C
View Scheme
参考文献
Gathirwa, Jeremiah W.; Maki, Toshihide
Synthetic Communications, 2013 , vol. 43, # 7 p. 1016 - 1022
反应条件
1: 4-(N,N-dimethlyamino)pyridine / dichloromethane / 12 h / 20 °C
2: zirconium tetrachloride / 1,2-dichloro-benzene / 2 h / 170 °C
3: hydrogenchloride / 1,2-dichloro-benzene / 12 h / 20 °C
4: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C
5: sodium hydroxide / tetrahydrofuran; water / 3 h / 20 °C
6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C
View Scheme
参考文献
Gathirwa, Jeremiah W.; Maki, Toshihide
Synthetic Communications, 2013 , vol. 43, # 7 p. 1016 - 1022
