chloroform

1: H2O / 37 °C / pH 7.4; apparent rate constant of product formation; calculated nasal absorption rate constant 2: 70 percent / perchloric acid / ethyl acetate / 5 h / Heating View Scheme

hydrazine

ammonia Multistep reaction;

chloroform Hydrolyse des Reaktionsprodukts;

nachfolgend Verseifen;

1: 82.6 percent / NaHCO3 / methanol; tetrahydrofuran / 20 h / Ambient temperature 2: 92 percent / K2CO3 / acetone / 24 h / Ambient temperature 3: 99 percent / NaOH / ethanol / Ambient temperature 4: 73.9 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole, Et3N / dimethylformamide / 20 h / Ambient temperature 5: 91 percent / HCl / dioxane / 2 h / Ambient temperature 6: 72 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole, Et3N / dimethylformamide / 24 h / Ambient temperature 7: 96 percent / HCl / dioxane / 2 h / Ambient temperature 8: 13.5 percent / Et3N / CH2Cl2 / 1.) -60 deg C, 30 min, 2.) 10 deg C, 1 h 9: 14 percent / m-CPBA / CH2Cl2 / 48 h / Ambient temperature View Scheme

1: aq. Na2CO3 2: aq. NaOH / dioxane View Scheme

1,1'-carbonyldiimidazole

ethyl acetate