4'-氟-3'-羟基苯乙酮合成路线 （共 4 条）
反应条件
sodium carbonate in N,N-dimethyl-formamide T=90°C;
参考文献
AMGEN INC.; MEMORY PHARMACEUTICALS CORPORATION
Patent: WO2007/103260 A1, 2007 ;
Location in patent: Page/Page column 64 ;
WO 2007/103260 A1
反应条件
1: With sulfuric acid; sodium nitrite in water
T=0 - 5°C;
2: With copper(I) oxide; sulfuric acid; water; copper(II) nitrate
T=20°C; 0.25 h;
参考文献
AMGEN INC.; MEMORY PHARMACEUTICALS CORPORATION
Patent: WO2007/103260 A1, 2007 ;
Location in patent: Page/Page column 64 ;
WO 2007/103260 A1
反应条件
water; hydrogen bromide
16 h; Heating / reflux;
参考文献
CRYPTOPHARMA PTY LTD
Patent: WO2008/124878 A1, 2008 ;
Location in patent: Page/Page column 128-129 ;
反应条件
perchloric acid in acetonitrile
Irradiation;
参考文献
Ramseier, Markus; Senn, Paul; Wirz, Jakob
Journal of Physical Chemistry A, 2003 , vol. 107, # 18 p. 3305 - 3315
