2-烯丙基-3-甲氧基苯甲醛合成路线 （共 14 条）
反应条件
1.1: tert-butyl methyl ether / 20 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: phenyllithium / anhydrous butyl ether / 35 °C
3.1: copper (I) cyanide / anhydrous butyl ether / 20 °C
4.1: anhydrous butyl ether
5.1: water; sodium sulfite / anhydrous butyl ether
View Scheme
参考文献
United Therapeutics Corporation
Patent: US2012/226076 A1, 2012 ;
反应条件
1: 3-(allyloxy)benzaldehyde in decalin
Claisen rearrangement; Reflux;
2: methyl iodide With potassium carbonate
参考文献
Chang, Meng-Yang; Wu, Ming-Hao; Lee, Nein-Chia; Lee, Ming-Fang
Tetrahedron Letters, 2012 , vol. 53, # 16 p. 2125 - 2128
参考文献
Chang, Meng-Yang; Chan, Chieh-Kai; Lin, Shin-Ying
Tetrahedron, 2013 , vol. 69, # 5 p. 1532 - 1538
反应条件
1: With oxygen; copper dichloride; palladium dichloride in tetrahydrofuran; methanol
T=20°C; 10 h;
2: With sodium hydroxide in tetrahydrofuran; methanol
T=20°C; 5 h;
参考文献
Chang, Meng-Yang; Chan, Chieh-Kai; Lin, Shin-Ying
Tetrahedron, 2013 , vol. 69, # 5 p. 1532 - 1538
