2-溴-6,7-二氢噻吩并[3,2-C]吡啶--5(4H)-甲酸叔丁酯合成路线 （共 5 条）
反应条件
sodium hydroxide in 1,4-dioxane
参考文献
US6015817 A1, ;
US 6015817 A
反应条件
triethylamine in dichloromethane 0.75 h; Cooling with ice;
参考文献
WO2011/110219 A1, ;
Page/Page column 15; 1 ;
反应条件
1.1: bromine / dichloromethane; water / 20 °C / pH 8.5 1.2: pH 8.5 / Alkaline conditions 2.1: triethylamine / dichloromethane / 0.75 h / Cooling with ice View Scheme
反应条件
1.1: potassium phosphate; copper; copper(l) iodide / 2-(dimethylamino)-ethanol / 24 h / 80 °C 2.1: hydrogenchloride / diethyl ether / Cooling with ice 3.1: triethylamine / acetonitrile / Cooling with ice 4.1: hydrogenchloride; water / 5 h / 70 °C 4.2: pH 10 / Alkaline conditions 5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 5 °C View Scheme
反应条件
1.1: potassium phosphate; copper; copper(l) iodide / 2-(dimethylamino)-ethanol / 24 h / 80 °C 2.1: hydrogenchloride / diethyl ether / Cooling with ice 3.1: triethylamine / acetonitrile / Cooling with ice 4.1: hydrogenchloride; water / 5 h / 70 °C 4.2: pH 10 / Alkaline conditions View Scheme
参考文献
SYNTHON BV; THIJS, Lambertus; ZHU, Jie; OVEREEM, Arjanne; KELTJENS, Rolf
Patent: WO2011/110219 A1, 2011 ;
