hydrogenchloride; iron in 2-methoxy-ethanol; water 1.16667 h; Heating;

1: 68 percent / TEA / CHCl3 / Ambient temperature 2: 53 percent / iron, conc. aq. HCl / 2-methoxy-ethanol; H2O / 1.17 h / Heating View Scheme

1: 68 percent / TEA / CHCl3 / Ambient temperature 2: 53 percent / iron, conc. aq. HCl / 2-methoxy-ethanol; H2O / 1.17 h / Heating View Scheme

1: 79 percent / 10percent aq. NaOH / dioxane / Ambient temperature 2: dicyclohexylcarbodiimide (DCC) / tetrahydrofuran; dimethylformamide / Ambient temperature 3: 68 percent / TEA / CHCl3 / Ambient temperature 4: 1.) trifluoroacetic acid (TFA), 2.) TEA / 1.) RT, 30 min, 2.) 2-methoxyethanol, reflux, 20 min View Scheme

1: dicyclohexylcarbodiimide (DCC) / tetrahydrofuran; dimethylformamide / Ambient temperature 2: 68 percent / TEA / CHCl3 / Ambient temperature 3: 1.) trifluoroacetic acid (TFA), 2.) TEA / 1.) RT, 30 min, 2.) 2-methoxyethanol, reflux, 20 min View Scheme

TEA; trifluoroacetic acid 1.) RT, 30 min, 2.) 2-methoxyethanol, reflux, 20 min; Yield given. Multistep reaction;