4-氨基-2-甲基-5-(氨甲基)嘧啶合成路线 （共 34 条）
反应条件
1: 4-amino-5-aminomethyl-2-methyl-pyrimidine With hydrogenchloride; formic acid
Inert atmosphereReflux;
2: C8H12O4S Reflux; Overall yield = 91.8 percentChromat.;
参考文献
DSM IP ASSETS B.V.; PENG, Kun; DAI, Xixiang; ZHAO, Lizhi; CAO, Weifeng; LETINOIS, Ulla
Patent: WO2014/29320 A1, 2014 ;
Location in patent: Page/Page column 10; 11 ;
反应条件
1: 4-amino-5-aminomethyl-2-methyl-pyrimidine With formic acid
RefluxInert atmosphere;
2: 3-Mercapto-4-oxopentyl Acetate Reflux; Overall yield = 78.0 percentChromat.;
参考文献
DSM IP ASSETS B.V.; PENG, Kun; DAI, Xixiang; ZHAO, Lizhi; CAO, Weifeng; LETINOIS, Ulla
Patent: WO2014/29320 A1, 2014 ;
Location in patent: Page/Page column 10 ;
参考文献
Matsukawa; Yurugi
Yakugaku Zasshi, 1949 , vol. 69, p. 508,509
Chem.Abstr., 1950 , p. 4476
反应条件
1: NaOH; methanol; ethanol
2: aq. NaOH solution
View Scheme
参考文献
Tomita et al.
Yakugaku Zasshi, 1948 , vol. 68, p. 151
Chem.Abstr., 1954 , p. 3984
