1: 2-chloro-aniline With hydrogenchloride; sodium nitrite in water
T=0 - 5°C;
2: 2-acetyl-thiophene With CuCl2·2H2O in water; acetone
Meerwein arylation;
参考文献
Matiychuk; Obushak; Lytvyn; Horak, Yu. I.
Chemistry of Heterocyclic Compounds, 2010 , vol. 46, # 1 p. 50 - 55
1: cuprous chloride, N-ethylmorpholine / benzene; various solvent(s) / 1 h / 120 °C
2: polyphosphoric acid / 1 h / 120 °C
3: SOCl2 / 1 h / Heating
4: CH2Cl2 / 0.5 h / 20 °C
5: NH3(g) / various solvent(s) / 0.25 h / 110 - 120 °C
View Scheme
参考文献
Rewcastle, Gordon W.; Atwell, Graham J.; Chambers, David; Baguley, Bruce C.; Denny, William A.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 4 p. 472 - 477