反应条件
1: pyridine / 1 h 2: conc. HNO3, conc. H2SO4 / a) from 0 deg C to RT, 1 h, b) 50 deg C, 20 min 3: 2 M NaOH / methanol / 1 h / Heating 4: H2 / 10percent Pd/C / ethanol / 3 h / 760 Torr View Scheme
参考文献
Chancellor, Daniel R.; Davies, Kay E.; De Moor, Olivier; Dorgan, Colin R.; Johnson, Peter D.; Lambert, Adam G.; Lawrence, Daniel; Lecci, Cristina; Maillol, Carole; Middleton, Penny J.; Nugent, Gary; Poignant, Severine D.; Potter, Allyson C.; Price, Paul D.; Pye, Richard J.; Storer, Richard; Tinsley, Jonathon M.; Van Well, Renate; Vickers, Richard; Vile, Julia; Wilkes, Fraser J.; Wilson, Francis X.; Wren, Stephen P.; Wynne, Graham M.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 9 p. 3241 - 3250
