4-氯-1,2-苯二胺合成路线 （共 167 条）
反应条件
1: sodium acetate; aqueous acetic acid
2: platinum; benzene / 2206.5 - 4413.05 Torr / Hydrogenation
View Scheme
参考文献
Cavagnol; Wiselogle
Journal of the American Chemical Society, 1947 , vol. 69, p. 795,796
反应条件
1: in methanol
0.166667 h; Reflux;
2: With trichlorophosphate in methanol; acetonitrile
T=125°C; 0.5 h; Microwave irradiation; Overall yield = 1 g;
参考文献
H. LUNDBECK A/S; JØRGENSEN, Morten; BRUUN, Anne, Techau; RASMUSSEN, Lars, Kyhn; LARSEN, Mogens
Patent: WO2013/34755 A1, 2013 ;
Location in patent: Page/Page column 19 ;
反应条件
1: ethanol / 16 h / Reflux
2: trichlorophosphate / 2.5 h / 90 °C
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GmbH; LANKAU, Hans-Joachim; LANGEN, Barbara; GRUNWALD, Christian; HOeFGEN, Norbert; STANGE, Hans; DOST, Rita; EGERLAND, Ute
Patent: WO2012/104293 A1, 2012 ;
WO 2012/104293 A1
反应条件
1: 53 percent / potassium hydroxide / ethanol / 2 h / 70 °C
2: 79 percent / potassium hydroxide / ethanol; H2O / 1 h / 20 °C
View Scheme
参考文献
Valdez, Juan; Cedillo, Roberto; Hernandez-Campos, Alicia; Yepez, Lilian; Hernandez-Luis, Francisco; Navarrete-Vazquez, Gabriel; Tapia, Amparo; Cortes, Rafael; Hernandez, Manuel; Castillo, Rafael
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 16 p. 2221 - 2224
反应条件
in acetic acid
8 h; heating in boiling-water bath; Title compound not separated from byproducts;
参考文献
Sallam, Mohammed A. E.; Whistler, Roy L.; Markley, John L.
Carbohydrate Research, 1980 , vol. 87, p. 87 - 98
反应条件
sodium amide in toluene
20 h; Heating;
参考文献
Wagner, Edwin
Polish Journal of Chemistry, 1982 , vol. 56, # 1 p. 131 - 139
反应条件
sodium amide in toluene
20 h; Heating;
参考文献
Wagner, Edwin
Polish Journal of Chemistry, 1982 , vol. 56, # 1 p. 131 - 139
反应条件
in xylene
3 h; Heating;
参考文献
Pennini; Cerri; Tajana; Nardi; Giordano
Journal of Heterocyclic Chemistry, 1988 , vol. 25, # 1 p. 305 - 310
反应条件
sulfur
T=160°C; 8 h;
参考文献
Tsukamoto; Yoshino; Kohno; Ohtaka; Kagaya; Ito
Journal of Medicinal Chemistry, 1980 , vol. 23, # 7 p. 734 - 738
反应条件
1,4-diaza-bicyclo[2.2.2]octane in 1-methyl-2-pyrrolidinone
T=100°C;
参考文献
Shen, Wang; Kohn, Todd; Fu, Zice; Jiao, XianYun; Lai, Sujen; Schmitt, Michael
Tetrahedron Letters, 2008 , vol. 49, # 51 p. 7284 - 7286
