4-氯-1,2-苯二胺合成路线 （共 167 条）
反应条件
zirconium(IV) oxychloride octahydrate
0.133333 h; Microwave irradiation;
参考文献
Sanjeeva Reddy; Nagaraj
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2008 , vol. 47, # 7 p. 1154 - 1159
参考文献
Adams; Winnick
Journal of the American Chemical Society, 1951 , vol. 73, p. 5687,5690
反应条件
in (+)-Norephedrine
T=180°C; 3.5 h;
参考文献
SCHERING CORPORATION
Patent: WO2008/108958 A2, 2008 ;
Location in patent: Page/Page column 51 ;
反应条件
1: 34 percent / KOH / xylene; ethanol; H2O / 5 h / 150 °C
2: 1.) K2CO3, Bu4N(1+)*HSO4(1-), 2.) aq. HCl / 1.) CH3CN, reflux, 2.) reflux
View Scheme
参考文献
Gomez-Parra, Vicente; Jimenez, Mercedes; Sanchez, Felix; Torres, Tomas
Liebigs Annalen der Chemie, 1989 , p. 539 - 544
反应条件
1: (i), (ii) N-chloro-succinimide
2: P2S5 / pyridine / Heating
3: KOH / dioxane; methanol
4: AcOH / xylene / Heating
View Scheme
参考文献
Press,J.B. et al.
Journal of Medicinal Chemistry, 1979 , vol. 22, p. 725 - 731
反应条件
Preyssler(NaH14P5W30O110, HPA)heteropolyacid in neat (no solvent)
T=120°C; 0.25 h;
参考文献
Pasquale, Gustavo A.; Ruiz, Diego M.; Jios, Jorge L.; Autino, Juan C.; Romanelli, Gustavo P.
Tetrahedron Letters, 2013 , vol. 54, # 48 p. 6574 - 6579
反应条件
gallium trifluoromethanesulfonate in ethanol
T=25°C; 24 h; Green chemistry;
参考文献
Huang, Shi-Gang; Mao, Hai-Feng; Zhou, Shao-Fang; Zou, Jian-Ping; Zhang, Wei
Tetrahedron Letters, 2013 , vol. 54, # 46 p. 6178 - 6180
参考文献
Tsukamoto; Yoshino; Kohno; Ohtaka; Kagaya; Ito
Journal of Medicinal Chemistry, 1980 , vol. 23, # 7 p. 734 - 738
反应条件
in xylene
T=138°C; 0.166667 h; Irradiation; Yield given;
参考文献
Bougrin, Khalid; Bennani, A. Kella; Tetouani, Souad Fkih; Soufiaoui, Mohamed
Tetrahedron Letters, 1994 , vol. 35, # 45 p. 8373 - 8376
反应条件
1: hydrogenchloride / water / 6 h / Reflux
2: tetrabutylammomium bromide; potassium hydroxide / tetrahydrofuran / 0 °C
View Scheme
参考文献
Eom, Young Woo; Oh, Sangtae; Woo, Ho Bum; Ham, Jungyeob; Ahn, Chan Mug; Lee, Seokjoon
Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 4 p. 1272 - 1274
