4-氯-1,2-苯二胺合成路线 （共 167 条）
反应条件
1: acetic acid 2: bei Destillation View Scheme
参考文献
Ullmann; Mauthner
Chemische Berichte, 1903 , vol. 36, p. 4032
参考文献
Eastman Kodak Co.
Patent: US2739149 , 1953 ;
反应条件
1: ethanol 2: POCl3 / dimethylformamide / 1.5 h View Scheme
参考文献
KALYPSYS, INC.; BORCHARDT, Allen; DAVIS, Robert; BEAUREGARD, Clay; BECKER, Daniel; GAMACHE, Daniel; NOBLE, Stewart, A.; HELLBERG, Mark, R.; KLIMKO, Peter, G.; ZHIHAI, Qui; PAYNE, Joseph, E.; YANNI, John
Patent: WO2011/112731 A2, 2011 ;
WO 2011/112731 A2
反应条件
potassium carbonate in N-methyl-acetamide; methanol; dichloromethane
参考文献
Warner-Lambert Company
Patent: US4714762 A1, 1987 ;
反应条件
hydrogenchloride 7.5 h; Heating;
参考文献
Raban, Morton; Chang, Hu; Craine, Leslie; Hortelano, Edwin
Journal of Organic Chemistry, 1985 , vol. 50, # 13 p. 2205 - 2210
反应条件
1: SOCl2, Py / 75 - 80 °C 2: NaNO3, H2SO4 / 95 - 100 °C View Scheme
参考文献
Pesin,V.G.; Sergeev,V.A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1967 , vol. 3, p. 662 - 666
Khimiya Geterotsiklicheskikh Soedinenii, 1967 , vol. 3, # 5 p. 839 - 844
反应条件
in methanol; water 24 h; Ambient temperature;
参考文献
Jacobsen, E. Jon; TenBrink, Ruth E.; Stelzer, Lindsay S.; Belonga, Kenneth L.; Carter, Donald B.; Im, Haesook K.; Im, Wha Bin; Sethy, Vimala H.; Tang, Andy H.; VonVoigtlander, Philip F.; Petke, James D.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 158 - 175
反应条件
selenium(IV) oxide in ethanol 0.5 h; Heating;
参考文献
Keana; Kher; Sui Xiong Cai; Dinsmore; Glenn; Guastella; Huang; Ilyin; Lu; Mouser; Woodward; Weber
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4367 - 4379
反应条件
in ethanol 0.5 h; Reflux;
参考文献
MERCK and CO., INC.
Patent: WO2008/153852 A1, 2008 ;
Location in patent: Page/Page column 73 ;
WO 2008/153852 A1
反应条件
hydrogenchloride Heating;
参考文献
Navarrete-Vazquez, Gabriel; Rojano-Vilchis, Maria De Monserrat; Yepez-Mulia, Lilian; Melendez, Victor; Gerena, Lucia; Hernandez-Campos, Alicia; Castillo, Rafael; Hernandez-Luis, Francisco
European Journal of Medicinal Chemistry, 2006 , vol. 41, # 1 p. 135 - 141
