2-氨基-4-甲基苯酚合成路线 （共 127 条）
反应条件
hydroxide; urea
Multistep reaction;
参考文献
Sheradsky, Tuvia; Nov, Eliahu
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2781 - 2786
反应条件
potassium hydroxide in methanol
3 h; Ambient temperature;
参考文献
Ueno; Maeda; Koshitan
Journal of Heterocyclic Chemistry, 1982 , vol. 19, # 1 p. 189 - 191
反应条件
1: sodium hydrogencarbonate / 2-methoxy-ethanol / 4 h / 40 °C
2: toluene-4-sulfonic acid / 1,2-dichloro-benzene / 3 h / 175 °C
View Scheme
参考文献
BAYER PHARMA AKTIENGESELLSCHAFT; HAHN, Michael; FOLLMANN, Markus; HÜBSCH, Walter; BECKER, Eva-Maria; STASCH, Johannes-Peter; KELDENICH, Joerg; DELBECK, Martina; TINEL, Hanna; WUNDER, Frank; MITTENDORF, Joachim; TEREBESI, Ildiko; LANG, Dieter; MARTIN, René
Patent: US2014/31391 A1, 2014 ;
反应条件
1: 55 percent / dimethylformamide / 5 h / Heating
2: 92 percent / aq. 1M NaOH / 3.5 h / 0 °C
View Scheme
参考文献
Liacha, Messaoud; Yous, Said; Depreux, Patrick; Poupaert, Jacques H.; Lesieur, Daniel
Heterocycles, 1999 , vol. 51, # 8 p. 1929 - 1943
反应条件
hydrogenchloride; sodium nitrite in water
T=0°C;
参考文献
Haberfield, Paul; Cardona, Claudia; Bell, Mark
Journal of Organic Chemistry, 1984 , vol. 49, p. 78 - 79
反应条件
triphenylphosphine in dichloromethane
T=20°C; 24 h;
参考文献
Yavari, Issa; Souri, Sanaz; Sirouspour, Mehdi; Djahaniani, Hoorieh
Synthesis, 2006 , # 19 p. 3243 - 3249
反应条件
2: Lawesson's reagent
3: dimethylformamide / Heating
4: cyclodehydration
View Scheme
参考文献
Shridhar, D. R.; Jogibhukta, M.; Krishnan, V. S. H.; Joshi, P. P.; Naidu, M. U. R.; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 12 p. 1279 - 1283
反应条件
sodium hydrogencarbonate in ethanol; water
T=20°C; 168000 h;
参考文献
Oezaytekin, Ilkay; Karatas, Ibrahim
Journal of Heterocyclic Chemistry, 2005 , vol. 42, # 7 p. 1283 - 1287
参考文献
IMPERIAL CHEMICAL INDUSTRIES PLC
Patent: EP611050 A1, 1994 ;
参考文献
IMPERIAL CHEMICAL INDUSTRIES PLC
Patent: EP611050 A1, 1994 ;
