反应条件
1: 1.) t-BuNH2, Br2, 2.) 4-(dimethylamino)pyridine / 1.) toluene + CH2Cl2, from -78 to RT, 5 h, 2.) pyridine, room temp., 24 h
2: 94 percent / n-BuLi / tetrahydrofuran / 10 h / -78 - 20 °C
3: 65 percent / conc. HCl / methanol / 3 h / Heating
4: 68 percent / N-bromosuccinimide / toluene; CH2Cl2 / 10 h / 1.) -78 deg C, 5 mni, 2.) RT, 10 h
5: 1.) NaH / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 3 h
6: 89 percent / n-BuLi / tetrahydrofuran; hexane / 7 h / -78 - 20 °C
7: 84 percent / NaI, trimethylsilyl chloride / acetonitrile / 3 h / Ambient temperature
View Scheme
参考文献
Jung; Koreeda
Journal of Organic Chemistry, 1989 , vol. 54, # 24 p. 5667 - 5675
