反应条件
1: 1.) t-BuNH2, Br2, 2.) 4-(dimethylamino)pyridine / 1.) toluene + CH2Cl2, from -78 to RT, 5 h, 2.) pyridine, room temp., 24 h
2: 94 percent / n-BuLi / tetrahydrofuran / 10 h / -78 - 20 °C
3: 65 percent / conc. HCl / methanol / 3 h / Heating
View Scheme
参考文献
Jung; Koreeda
Journal of Organic Chemistry, 1989 , vol. 54, # 24 p. 5667 - 5675
