3-氯-2,5-二甲基吡嗪合成路线 （共 32 条）
反应条件
potassium acetate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=100°C; 2 h;
参考文献
Akita, Yasuo; Inoue, Akira; Ohta, Akihiro
Chemical & Pharmaceutical Bulletin, 1986 , vol. 34, # 4 p. 1447 - 1458
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium acetate in N,N-dimethyl acetamide 12 h; Heating;
参考文献
Heterocycles, , vol. 33, # 1 p. 257 - 272
反应条件
sodium hydroxide; tetrakis(triphenylphosphine) palladium(0); potassium acetate 1.) N,N-dimethylacetamide, reflux, 12 h, 2.) dioxane, MeOH, RT, 12 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Heterocycles, , vol. 33, # 1 p. 257 - 272
反应条件
1: propyl bromide With iron (III) acetylacetonate; magnesium in tetrahydrofuran 2: 3-chloro-2,5-dimethyl-pyrazine With 1-methyl-pyrrolidin-2-one T=0°C; 0.25 h;
参考文献
Dickschat, Jeroen S.; Wickel, Susanne; Bolten, Christoph J.; Nawrath, Thorben; Schulz, Stefan; Wittmann, Christoph
European Journal of Organic Chemistry, 2010 , # 14 p. 2687 - 2695
反应条件
sodium perborate in acetic acid T=80°C; 24 h;
参考文献
Ohta, Akihiro; Ohta, Masakatsu
Synthesis, 1985 , # 2 p. 216 - 217
反应条件
ammonia; copper in water T=150°C; 48 h; Autoclave;
参考文献
Sunovion Pharmaceuticals Inc.
Patent: US2012/178748 A1, 2012 ;
Location in patent: Page/Page column 37 ;
US 20120178748 A1
反应条件
tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane; hexane 2 h; Heating;
参考文献
Ohta, Akihiro; Inoue, Akira; Watanabe, Tokuhiro
Heterocycles, 1984 , vol. 22, # 10 p. 2317 - 2321
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in N,N-dimethyl-formamide Heating;
参考文献
Heterocycles, , vol. 26, # 9 p. 2449 - 2454
反应条件
tetrakis(triphenylphosphine) palladium(0); diethylzinc; potassium carbonate in N,N-dimethyl-formamide Heating;
参考文献
Heterocycles, , vol. 26, # 9 p. 2449 - 2454
反应条件
iron (III) acetylacetonate in tetrahydrofuran; 1-methyl-pyrrolidin-2-one T=0°C; Grignard reaction; 0.25 h;
参考文献
Dickschat, Jeroen S.; Reichenbach, Hans; Wagner-Doebler, Irene; Schulz, Stefan
European Journal of Organic Chemistry, 2005 , # 19 p. 4141 - 4153
