3-氯-2,5-二甲基吡嗪合成路线 （共 32 条）
反应条件
sodium hydroxide; tetrakis(triphenylphosphine) palladium(0); potassium acetate 1.) N,N-dimethylacetamide, reflux, 12 h, 2.) dioxane, MeOH, RT, 12 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Aoyagi, Yutaka; Inoue, Akira; Koizumi, Isamu; Hashimoto, Rie; Tokunaga, Kazuko; et al.
Heterocycles, 1992 , vol. 33, # 1 p. 257 - 272
反应条件
1: acetic acid; aqueous H2O2
2: POCl3
View Scheme
参考文献
Baxter et al.
Journal of the Chemical Society, 1948 , p. 1859,1861
反应条件
iron (III) acetylacetonate in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=0°C; Grignard reaction; 0.25 h;
参考文献
Dickschat, Jeroen S.; Reichenbach, Hans; Wagner-Doebler, Irene; Schulz, Stefan
European Journal of Organic Chemistry, 2005 , # 19 p. 4141 - 4153
反应条件
sodium azide in N,N-dimethyl-formamide
10 h; Heating;
参考文献
Watanabe, T.; Nishiyama, J.; Hirate, R.; Uehara, K.; Inoue, M.; et al.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1277 - 1281
反应条件
1: ethyl bromide With magnesium in tetrahydrofuran
2: 3-chloro-2,5-dimethyl-pyrazine With 1-methyl-pyrrolidin-2-one; iron (III) acetylacetonate
T=0°C; 0.25 h;
参考文献
Dickschat, Jeroen S.; Wickel, Susanne; Bolten, Christoph J.; Nawrath, Thorben; Schulz, Stefan; Wittmann, Christoph
European Journal of Organic Chemistry, 2010 , # 14 p. 2687 - 2695
反应条件
[1,3-bis(diphenylphosphino) propane] dichloronickel(II) in tetrahydrofuran; hexane
3 h; Ambient temperature;
参考文献
Sato, Nobuhiro; Matsuura, Tomoyuki
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 19 p. 2345 - 2350
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in N,N-dimethyl-formamide
Heating;
参考文献
Ohta, Akihiro; Ohta, Masakatsu; Igarashi, Yoshiaki; Saeki, Kaemi; Yuasa, Kayo; Mori, Tomoko
Heterocycles, 1987 , vol. 26, # 9 p. 2449 - 2454
反应条件
tetrakis(triphenylphosphine) palladium(0); diethylzinc; potassium carbonate in N,N-dimethyl-formamide
Heating;
参考文献
Ohta, Akihiro; Ohta, Masakatsu; Igarashi, Yoshiaki; Saeki, Kaemi; Yuasa, Kayo; Mori, Tomoko
Heterocycles, 1987 , vol. 26, # 9 p. 2449 - 2454
反应条件
[1,3-bis(diphenylphosphino) propane] dichloronickel(II) in tetrahydrofuran
8 h;
参考文献
Sato, Nobuhiro; Matsuura, Tomoyuki
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 19 p. 2345 - 2350
反应条件
sodium thiomethoxide in ethylene glycol dimethyl ether
T=150°C; 12 h;
参考文献
Dickschat, Jeroen S.; Reichenbach, Hans; Wagner-Doebler, Irene; Schulz, Stefan
European Journal of Organic Chemistry, 2005 , # 19 p. 4141 - 4153
