1.1: 4 h / 135 °C 2.1: methanesulfonic acid; phosphorous pentoxide / 4 h / 40 °C 3.1: methanol; potassium acetate / 0.25 h / Reflux 4.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 12 h / 20 °C 5.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere 5.2: -78 - 20 °C / Inert atmosphere 6.1: tetrabutyl ammonium fluoride; water / ethyl acetate / 0.17 h / 20 °C 7.1: 10 palladium on activated charcoal; hydrogen; ethylenediamine / methanol / 1 h / 20 °C / 760.05 Torr View Scheme

1.1: 4 h / 135 °C 2.1: methanesulfonic acid; phosphorous pentoxide / 4 h / 40 °C 3.1: methanol; potassium acetate / 0.25 h / Reflux 4.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 12 h / 20 °C 5.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere 5.2: -78 - 20 °C / Inert atmosphere 6.1: quinoline; hydrogen / hexane; toluene / 1 h / 20 °C / 760.05 Torr 6.2: 0.25 h / 20 °C View Scheme

1: tetrabutyl ammonium fluoride; water / ethyl acetate / 0.17 h / 20 °C 2: 10 palladium on activated charcoal; hydrogen; ethylenediamine / methanol / 1 h / 20 °C / 760.05 Torr View Scheme

1.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 12 h / 20 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere 2.2: -78 - 20 °C / Inert atmosphere 3.1: tetrabutyl ammonium fluoride; water / ethyl acetate / 0.17 h / 20 °C 4.1: 10 palladium on activated charcoal; hydrogen; ethylenediamine / methanol / 1 h / 20 °C / 760.05 Torr View Scheme

1.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 12 h / 20 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere 2.2: -78 - 20 °C / Inert atmosphere 3.1: quinoline; hydrogen / hexane; toluene / 1 h / 20 °C / 760.05 Torr 3.2: 0.25 h / 20 °C View Scheme

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere 1.2: -78 - 20 °C / Inert atmosphere 2.1: tetrabutyl ammonium fluoride; water / ethyl acetate / 0.17 h / 20 °C 3.1: 10 palladium on activated charcoal; hydrogen; ethylenediamine / methanol / 1 h / 20 °C / 760.05 Torr View Scheme

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere 1.2: -78 - 20 °C / Inert atmosphere 2.1: quinoline; hydrogen / hexane; toluene / 1 h / 20 °C / 760.05 Torr 2.2: 0.25 h / 20 °C View Scheme